Translation of circular RNAs (circRNAs) now has drawn increasing attention from researchers due to their emerging roles of the functional peptides encoded by circRNAs as new players involved in the regulation of gene expression. However, the scope of circRNA translation is not yet clear. To this end, we analyzed 3,184 publicly available Ribo-seq datasets and 1,986 matched RNA-seq datasets from the same samples involving 321 studies covering 33 species to determine the prevalence of circRNA translation, and meanwhile designed a dedicated database named riboCIRC, which aims to provide: (1) a comprehensive atlas of computationally predicted translatable circRNAs, (2) a manually curated collection of experimentally verified translatable circRNAs, (3) a systematic de novo sequence, structural, and functional annotation of circRNA-encoded peptides, and (4) a context-specific ribosome footprint view of translatable circRNAs. This database will serve as an important novel resource for bench and computational biologists to explore translated circRNAs and to drive functional investigation of circRNA translation.

Currently the database contains a total of 0 computationally predicted translatable circRNAs across 0 different species (Human, Mouse, Rat, C.elegans, Drosophila and Zebrafish) and 0 experimentally verified translatable circRNAs.